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Linkage and linkage-disequilibrium (LD) analyses on chromosomal regions 6p21-p22, 15q21 and 18p11 in reading and spelling disorder (dyslexia)

G. Schulte-Korne , M. Manthey , I. R. Koenig , T. Grimm , J. Schumacher , M. Duell ,A. Warnke , E. Plume , S. Cichon , H. Remschmidt , A. Ziegler , P. Propping , M. M. Nothen

(1) Univ. Marburg, Germany (2) Univ. Bonn, Germany (3) Univ. Lübeck, Germany (4) Univ. Würzburg, Germany (6) Univ. Antwerpen, Belgium schulte1@med.uni-marburg.de

Abstract

Linkage studies have previously identified regions likely to contain genes contributing to dyslexia, including regions on the long arm of chromosome 6, 15 and the short arm of chromosome 18. We have previously reported supportive evidence for linkage on chromosome 15q21 in seven German multiplex families with dyslexia. Since this chromosomal region was suggested by independent groups, we regard it a promising susceptibility locus for dyslexia. In an attempt to narrow down the region of interest, we are genotyping a total of 150 dyslexia families using 19 STR markers, covering a 24 Mb interval on 15q21. In additon to linkage analysis, we are performing transmission disequilibrium analysis in 124 triads using five 15q21 markers that were previously associated with dyslexia in a UK sample. On 18p11, significant linkage with dyslexia was previously reported in two independent samples. In order to evaluate this chromosomal region in our families with dyslexia, we are genotyping 14 markers covering a 38 Mb interval. Since intermarker distances around the linkage peak are small, these markers will also be used for an initial search for LD in the triad sample. On 6p21-p22 linkage with dyslexia and related phenotypes were reported in several independant samples. In order to evaluate this chromosomal region in our families with dyslexia, we are genotyping 11 markers. Our study is a first step towards identifying susceptibility genes for dyslexia.

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